Robert P Mecham Selected Research

Supravalvular Aortic Stenosis (Aortic Supravalvular Stenosis)

1/2020	Whole exome sequencing in patients with Williams-Beuren syndrome followed by disease modeling in mice points to four novel pathways that may modify stenosis risk.
12/2011	Genetic modifiers of cardiovascular phenotype caused by elastin haploinsufficiency act by extrinsic noncomplementation.
12/2009	Discrete contributions of elastic fiber components to arterial development and mechanical compliance.
11/2008	Elastin insufficiency predisposes to elevated pulmonary circulatory pressures through changes in elastic artery structure.
2/2008	Elastin haploinsufficiency induces alternative aging processes in the aorta.
8/2007	Functional rescue of elastin insufficiency in mice by the human elastin gene: implications for mouse models of human disease.
7/2007	Elastin-insufficient mice show normal cardiovascular remodeling in 2K1C hypertension despite higher baseline pressure and unique cardiovascular architecture.
2/2007	Domains 16 and 17 of tropoelastin in elastic fibre formation.
9/2005	Effects of elastin haploinsufficiency on the mechanical behavior of mouse arteries.
11/2003	Developmental adaptation of the mouse cardiovascular system to elastin haploinsufficiency.

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Robert P Mecham Research Topics

Disease

15	Hypertension (High Blood Pressure) 01/2021 - 02/2003
11	Supravalvular Aortic Stenosis (Aortic Supravalvular Stenosis) 01/2020 - 05/2003
7	Marfan Syndrome (Marfan's Syndrome) 01/2016 - 05/2004
6	Williams Syndrome (Williams-Beuren Syndrome) 01/2021 - 02/2008
6	Inflammation (Inflammations) 01/2016 - 02/2004
4	Aortic Diseases 01/2019 - 07/2008
4	Cutis Laxa 06/2012 - 05/2003
3	Cardiovascular Diseases (Cardiovascular Disease) 11/2019 - 07/2008
3	Aneurysm (Aneurysms) 01/2019 - 08/2017
3	Thoracic Aortic Aneurysm 01/2019 - 01/2016
3	recessive Cutis laxa 05/2017 - 12/2006
3	Obesity 01/2016 - 09/2008
3	Hemorrhage 09/2015 - 04/2008
3	Vascular Calcification 08/2011 - 01/2003
3	Emphysema 09/2010 - 03/2006
3	Vascular Remodeling 11/2008 - 02/2005
3	Hypoxia (Hypoxemia) 11/2008 - 09/2005
2	Neointima 12/2021 - 02/2005
2	Hyperplasia 12/2021 - 01/2017
2	Rupture 11/2020 - 01/2017
2	Abdominal Aortic Aneurysm 01/2020 - 01/2017
2	Diabetic Retinopathy (Retinopathy, Diabetic) 01/2019 - 01/2017
2	Atherosclerosis 01/2019 - 10/2014
2	Metabolic Diseases (Metabolic Disease) 10/2018 - 10/2014
2	Neoplasms (Cancer) 10/2018 - 01/2018
2	Aortic Aneurysm (Aneurysm, Aortic) 05/2017 - 09/2010
2	Cardiovascular Abnormalities 05/2017 - 10/2014
2	Fibrosis (Cirrhosis) 01/2017 - 08/2011
2	Wounds and Injuries (Trauma) 01/2016 - 09/2015
2	Disease Susceptibility (Diathesis) 09/2015 - 09/2008
2	Lung Injury 01/2015 - 03/2007
2	Hyperglycemia 10/2014 - 08/2003
2	Body Weight (Weight, Body) 10/2014 - 09/2008
2	Hypertrophy 10/2014 - 02/2008
2	Insulin Resistance 10/2014 - 08/2003
2	Autosomal Dominant Cutis Laxa 06/2012 - 09/2010
2	Essential Hypertension 06/2012 - 11/2003
2	Chronic Obstructive Pulmonary Disease (COPD) 07/2006 - 10/2005
1	Cantu syndrome 01/2021
1	Isolated Systolic Hypertension 01/2021
1	Coronary Disease (Coronary Heart Disease) 01/2021
1	COVID-19 12/2020
1	Psoriasis (Pustulosis Palmaris et Plantaris) 01/2019
1	Pathologic Constriction (Stenosis) 01/2017
1	Infertility (Sterility) 03/2016
1	Diabetic Nephropathies (Diabetic Nephropathy) 01/2016
1	Dyslipidemias (Dyslipidemia) 01/2016
1	Kidney Diseases (Kidney Disease) 01/2016
1	Hypertriglyceridemia 01/2016
1	Hereditary Nephritis (Alport Syndrome) 01/2016
1	Albuminuria 01/2016
1	Neutropenia 09/2015
1	Acromicric dysplasia 05/2015
1	Pulmonary Fibrosis (Fibrosing Alveolitis) 01/2015
1	Weight Loss (Weight Reduction) 01/2015

Drug/Important Bio-Agent (IBA)

40	ElastinIBA 12/2021 - 01/2003
10	Proteins (Proteins, Gene)FDA Link 01/2021 - 11/2003
8	CollagenIBA 11/2020 - 02/2008
8	Fibrillin-1IBA 01/2016 - 10/2003
5	Extracellular Matrix ProteinsIBA 01/2021 - 04/2004
3	LipidsIBA 01/2021 - 10/2014
3	Protein-Lysine 6-Oxidase (Lysyl Oxidase)IBA 01/2019 - 08/2017
3	Retinaldehyde (Retinal)IBA 01/2019 - 01/2003
3	microfibrillar proteinIBA 10/2018 - 09/2008
3	Biological ProductsIBA 01/2016 - 06/2004
3	FibrillinsIBA 05/2015 - 10/2003
3	TropoelastinIBA 09/2010 - 01/2003
2	1,3,4,6- tetra- O- acetyl- 2- azido- 2- deoxyglucopyranose (TAAD)IBA 08/2017 - 01/2016
2	Transforming Growth Factors (Transforming Growth Factor)IBA 05/2015 - 01/2015
2	Pancreatic Elastase (Elastase)IBA 07/2008 - 03/2006
2	SmokeIBA 03/2007 - 03/2006
2	Matrix Metalloproteinases (MMPs)IBA 03/2006 - 02/2004
2	Vasoconstrictor AgentsIBA 04/2003 - 02/2003
1	Adenosine Triphosphate (ATP)IBA 01/2021
1	von Willebrand FactorIBA 01/2021
1	KATP ChannelsIBA 01/2021
1	PotassiumIBA 01/2021
1	Epidermal Growth Factor (EGF)IBA 01/2021
1	Fibroblast Growth Factor Receptors (Fibroblast Growth Factor Receptor)IBA 01/2021
1	mRNA VaccinesIBA 12/2020
1	Lipoproteins (Lipoprotein)IBA 01/2019
1	Interleukin-17 (Interleukin 17)IBA 01/2019
1	Streptozocin (Streptozotocin)FDA Link 01/2019
1	Biomarkers (Surrogate Marker)IBA 10/2018
1	Small Interfering RNA (siRNA)IBA 01/2018
1	Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA 01/2018
1	Transcription Factors (Transcription Factor)IBA 01/2018
1	Phenobarbital (Luminal)FDA Link 01/2017
1	Carbon DioxideIBA 03/2016
1	Serum AlbuminIBA 01/2016
1	Collagen Type IV (Type IV Collagen)IBA 01/2016
1	Triglycerides (Triacylglycerol)IBA 01/2016
1	AlbuminsIBA 01/2016
1	Glycoproteins (Glycoprotein)IBA 05/2015
1	Evans Blue (Blue, Evans)FDA Link 01/2015
1	Coloring Agents (Dyes)IBA 01/2015
1	Fibroblast Growth Factors (Fibroblast Growth Factor)IBA 01/2015
1	Bleomycin (Blenoxane)FDA LinkGeneric 01/2015
1	Fibroblast Growth Factor 2 (Basic Fibroblast Growth Factor)IBA 01/2015

Therapy/Procedure

2	Therapeutics 01/2018 - 06/2012